Motivated by diseases arising from the misregulation of proteins and RNA, our biophysical approach makes connections between molecular mechanism and cellular function through time-resolved spectral imaging at multiple scales, from in vitro to single cell to whole organism.

We are part of the Chemistry Department at Yale University.

Recent Publications


C.M. Davis*, J. Deutsch, M. Gruebele*       

An in vitro mimic of in-cell solvation for protein folding studies

Prot. Sci., 2020, in press


R. Feng, M. Gruebele*, and C. M. Davis*

Quantifying protein dynamics and stability in a living organism

Nat. Commun., 2019, 10, 1179

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Y. Wang, S. Sukenik*, C.M. Davis, and

M. Gruebele*

Cell volume controls protein stability and compactness of the unfolded state

J. Phys. Chem. B, 2018, 122 (49), 11762-11770

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© 2019 Davis Lab

Davis Lab, Yale University

Department of Chemistry

255 Prospect St, KCL 108

New Haven, CT 06511