Motivated by diseases arising from the misregulation of proteins and RNA, our biophysical approach makes connections between molecular mechanism and cellular function through time-resolved spectral imaging at multiple scales, from in vitro to single cell to whole organism.

We are part of the Chemistry Department at Yale University.

Recent Publications


R. Feng, M. Gruebele*, and C. M. Davis*

Quantifying protein dynamics and stability in a living organism

Nat. Commun., 2019, 10, 1179

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Y. Wang, S. Sukenik*, C.M. Davis, and

M. Gruebele*

Cell volume controls protein stability and compactness of the unfolded state

J. Phys. Chem. B, 2018, 122 (49), 11762-11770


C.M. Davis, L.Z. Polzi, M. Gruebele, A. Amadei, R.B. Dyer*, I. Diadone*

A quantitative connection of experimental and simulated folding landscapes by vibrational spectroscopy

Chem. Sci., 2018, 9, 9002-9011

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© 2019 Davis Lab

Davis Lab, Yale University

Department of Chemistry

255 Prospect St, KCL 108

New Haven, CT 06511